Folding path of P5abc RNA involves direct coupling of secondary and tertiary structures

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Folding path of P5abc RNA involves direct coupling of secondary and tertiary structures

Folding mechanisms in which secondary structures are stabilized through the formation of tertiary interactions are well documented in protein folding but challenge the folding hierarchy normally assumed for RNA. However, it is increasingly clear that RNA could fold by a similar mechanism. P5abc, a small independently folding tertiary domain of the Tetrahymena thermophila group I ribozyme, is kn...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2012

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gks468